![]() ![]() The viruses able to replicate efficiently cause syncytium formation and are regularly isolated from immunodeficient patients. Except for a few isolates, the great majority of slow/low viruses replicate in peripheral blood mononuclear cells and Jurkat-tatIII cells constitutively expressing the tatIII gene of HIV-1. In contrast, slow/low viruses replicate transiently, if at all, in these cell lines. Rapid/high viruses can easily be transmitted to a variety of cell lines of T-lymphoid (CEM, H9, and Jurkat) and monocytoid (U937) origin. ![]() ![]() ABSTRACT According to their capacity to replicate in vitro, human immunodeficiency virus (HIV) isolates can be divided into two major groups, rapid/high and slow/low. E M Fenyö, L Morfeldt-Månson, F Chiodi, B Lind, A von Gegerfelt, J Albert, E Olausson and B Asjö Department of Virology, Karolinska Institutet, Stockholm, Sweden. Distinct replicative and cytopathic characteristics of human immunodeficiency virus isolates.įenyö, E M Morfeldt-Månson, L Chiodi, F Lind, B von Gegerfelt, A Albert, J Olausson, E Asjö, Bĭistinct replicative and cytopathic characteristics of human immunodeficiency virus isolates. Distinct replicative and cytopathic characteristics of human immunodeficiency virus isolates.
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